The most significant advantage of a portable DAC/AMP is, of course, portability. With a portable device, you can enjoy high-quality audio on the go, without having to carry around a bulky desktop unit. This makes portable DAC/AMP perfect for travel, commutes, or any situation where space is at a premium.

However, it's important to note that portability often comes at a cost. Portable DAC/AMPs are typically smaller and less powerful than their desktop counterparts, which can result in a loss of audio quality. This is especially true when using high-impedance headphones or in situations where you require more power to drive the headphones.

When it comes to audio quality, both portable and desktop DAC/AMP have their pros and cons. Desktop DAC/AMP typically offers better sound quality because of their larger size and the ability to incorporate higher quality components. They can also provide more power to drive headphones or speakers with ease.

However, portable DAC/AMPs are catching up with the advancements in technology. They offer a range of advanced features like the use of advanced DAC chips, higher sampling rates, and support for high-resolution audio formats. They can deliver great sound quality and performance in a compact package.

Finally, there's the question of ease of use. Portable DAC/AMPs often offer the convenience of a color display screen and physical volume keys, which make operation easy. Meanwhile, desktop DAC/AMP often requires more advanced setup and operation, which may be challenging for beginners.

In summary, the choice between portable and desktop DAC/AMP ultimately comes down to personal preference. If you prioritize portability and convenience, a portable DAC/AMP like the HiBy FC6 or the HiBy R3 PRO SABER 2022 might be a better choice. However, if you are more concerned about sound quality and have high-impedance headphones or speakers, a desktop DAC/AMP might be the better option. At the end of the day, it's all about finding the right balance between portability, audio quality, and ease of use to suit your individual needs.